The Paradigm of Autonomous Research | Francesco Pappone (CEO, Paradigma)
Francesco Pappone (@tensorqt) is building Paradigma - an infrastructure for autonomous research. Their product Flywheel replaces papers with directed acyclic graphs where every experiment is a node with tracked lineage, and AI agents traverse and extend the graph via MCP. In this conversation, we go through Francesco's path from physics to founding Paradigma, how Flywheel works, building from Rome, how it connects to Karpathy's autoresearch and the broader auto-research movement, the hard problems around trust and verification when AI runs experiments, and where autonomous research is headed. ----------- Francesco Pappone [Guest]: https://x.com/tensorqt Himanshu [Host at GroundZero]: https://x.com/himanshustwts Try Flywheel: https://flywheel.paradigma.inc GroundZero: https://groundzeroai.in ------------ To sponsor future episodes, visit https://www.groundzeroai.in/partner ------------ TIMESTAMPS: 00:00:00 - INTRO 00:01:03 - Dropping out of PhD, Saturation in Academia, Building from EU 00:13:15 - Autoresearch, Idea behind Flywheel, ex-OpenAI Co-founder 00:19:18 - Evals for Autoreserch and Research Taste 00:25:00 - How a Research Lab uses Flywheel? 00:31:15 - Thesis and Autoresearch Adoption in Top 5 Labs 00:41:00 - Working around with Flywheel, Combinatorial Explosion 01:02:03 - Science as Public Graph, Deriving New Research Loop, Quick Fire 01:06:23 - Toughest Autoresearch Challenge as of Today, Future Directions 01:11:53 - Automating Science: Sakana and Deepmind, Trust Problem? 01:21:07 - Business Model, Automating R&D, Model Capabilities 01:27:20 - Dropout of college to live on frontier!